The Longevity Reality Radar
46 approaches, rated by evidence.

Senolytics (dasatinib, quercetin, fisetin)

Senolytics (Dasatinib + Quercetin, Fisetin). Aging itself. Reviewed Jul 2026.

Small human studies show the drugs can be given, with off-target side effects, but no durable benefit in people has been shown.

Stage
Phase 1/2
Rung: In human trials. Phase 1 to 3. Being tested in people now. Most will not make it.
Evidence grade
C
small human studies
Small or uncontrolled human data, or strong animal data. How grades work.

What it is

Drugs that selectively kill senescent 'zombie' cells which accumulate with age and drive chronic inflammation.

The evidence

Early human studies show feasibility but also off-target cell loss and platelet effects; durable benefit still unproven.

What you can do today

Outside a registered clinical trial, this is not something you can responsibly get. If it is relevant to you, the route is a trial: ask your specialist, or search a trial registry such as ClinicalTrials.gov for studies you may qualify for.

Sources

No primary paper or registry record is linked for this entry yet. The evidence summary names the studies it relies on.

Change history

No ladder moves or corrections logged for this entry yet. Changes are dated on the change log.

Related

More in Aging itself

All 17 in Aging itself.

  • Rapamycin for longevityGrade C, strong animal data. Approved drug, off-label use.Extends lifespan across many animal species, but there is no human outcome data for longevity and side effects such as poor wound healing and infection are real.
  • Acarbose for longevityGrade C, strong animal data. Approved drug, off-label use.One of the most reproducible lifespan extenders in mice, mainly in males, but there is no human longevity trial.
  • VO₂max and strength for longevityGrade B, large cohorts. Established.In large observational cohorts the top VO₂max quartile has about 4 to 5 times lower all-cause mortality than the bottom, and nothing pharmacological on this list comes close.
  • RentosertibGrade C, post-hoc biomarker. Phase 3, for lung fibrosis.Six aging clocks moved in 42 lung-fibrosis patients over 12 weeks, a design that cannot separate slowed aging from a treated lung, and no healthy-volunteer or outcome data exist.
  • Partial epigenetic reprogramming (ER-100)Grade D, animal data only. Phase 1, in the eye.A first-in-human safety trial in the eye has started, but every efficacy result so far comes from animals.
  • Therapeutic plasma exchange for agingGrade C, small trial, surrogate. Early clinical.A small trial lowered biological-age scores by about 1.3 years, a surrogate marker, and there is no outcome data.

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