The Longevity Reality Radar
46 approaches, rated by evidence.

Inflammaging

Targeting 'inflammaging' (chronic low-grade inflammation). Aging itself. Reviewed Jul 2026.

Boosting one anti-inflammatory protein made old mice stronger, while human approaches remain early with no outcome data.

Stage
Preclinical
Rung: Experimental. Animal, lab or theoretical. Years away, if ever.
Evidence grade
D
one mouse study
Animal or lab only, single pilot, or case reports. How grades work.

What it is

Dialing down the persistent low-level inflammation that builds up with age and degrades muscle, brain and immune function.

The evidence

Mouse study: boosting the inflammation-controlling protein TTP made old mice stronger, healthier and more energetic. Human anti-inflammatory longevity strategies remain early.

What you can do today

Not available for this use, and years away if it arrives at all. Anything sold today with this claim is not backed by human evidence for it.

Sources

  • Coverage, not a sourcex.com

No primary paper or registry record is linked for this entry yet. The evidence summary names the studies it relies on.

Change history

No ladder moves or corrections logged for this entry yet. Changes are dated on the change log.

Related

More in Aging itself

All 17 in Aging itself.

  • Rapamycin for longevityGrade C, strong animal data. Approved drug, off-label use.Extends lifespan across many animal species, but there is no human outcome data for longevity and side effects such as poor wound healing and infection are real.
  • Acarbose for longevityGrade C, strong animal data. Approved drug, off-label use.One of the most reproducible lifespan extenders in mice, mainly in males, but there is no human longevity trial.
  • VO₂max and strength for longevityGrade B, large cohorts. Established.In large observational cohorts the top VO₂max quartile has about 4 to 5 times lower all-cause mortality than the bottom, and nothing pharmacological on this list comes close.
  • RentosertibGrade C, post-hoc biomarker. Phase 3, for lung fibrosis.Six aging clocks moved in 42 lung-fibrosis patients over 12 weeks, a design that cannot separate slowed aging from a treated lung, and no healthy-volunteer or outcome data exist.
  • Senolytics (dasatinib, quercetin, fisetin)Grade C, small human studies. Phase 1/2.Small human studies show the drugs can be given, with off-target side effects, but no durable benefit in people has been shown.
  • Partial epigenetic reprogramming (ER-100)Grade D, animal data only. Phase 1, in the eye.A first-in-human safety trial in the eye has started, but every efficacy result so far comes from animals.

Guides that cover this